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KMID : 0384119860060010139
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Korean Journal of Clinical Pathology
1986 Volume.6 No. 1 p.139 ~ p.142
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Two Cases of Sideroblastic Anemias Including One Case of Hereditary Sideroblastic Anemia
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김혜숙/Kim, Hye Sook
한경자/허미경/김병기/심상인/Han, Kyung Ja/Hur, Mi KyungKim, Byoung Kee/Shim, Sang In/Kim, Sun Moo
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Abstract
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Sideroblastic anemias are. a heterogenous group of disorders which have as a common feature the presence of large numbers of ring sideroblasts in the bone marrow, ineffective erythropoiesis and varying proportions of hypochromic erythrocytes in the peripheral blood.
Laboratory findings show increased serum iron, decreased TIBC and increased saturation of iron.
It may be acquired or hereditary.
The former may be primary or secondary to the administration of certain drugs, to toxins, or to neoplastic or inflammatory disease.
Hereditary sideroblastic anemia is a very rare disease and include both X chromosome linked and autosomal linked entities.
We found two cases of sideroblastic anemias.
One of these is hereditary sideroblastic anemia of an infant, 7-month-old male. Laboratory findings showed serum iron 256,eg/dl, TIBC 285jig/dl, dimorphism in the peripheral blood and erythroid hyperplasia of the bone marrow and 25% of all normoblasts are ring sideroblasts.
Another case is acquired primary sideroblastic anemia of an 69-year-old male. Laboratory findings showed serum iron 216pg/dl, TIBC 235,ag/dl, dimorphism in the peripheral blood and erythroid hyperplasia of the bone marrow with megaloblastoid changes and 57% of all nucleated erythrocytes are ring sideroblasts.
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